TB 500/BPC 157

TB 500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB 500). It is a first-in-class drug candidate that promotes the following: Endothelial (blood vessels) cell differentiation; Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues; Keratinocyte migration; Collagen deposition; and Decreases inflammation.One of TB 500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. TB 500 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.TB 500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.BPC 157 5mg is a small peptide made up of 15 amino acids, which are the building blocks of proteins. The peptide is derived from a portion of body protection compound (BPC) that is produced naturally by cells found in the stomach. The discovery that the peptide demonstrated strong organ protective and direct cell protection lead to it being developed further. Additional studies later revealed that treating with BPC 157 results in the healing of many different tissues, including skin, muscle, tendon, ligament and bone in animal studies. Studies also show that the effect of BPC 157 is long lasting due to the stability of the pentadecapeptide. BPC 157 will enhance the effects of human growth hormone by increasing the availability of the human growth hormone receptor. Therefore, using BPC 157 in combination with other peptides that increase the availability of human growth hormone will potentiate these effects.The reported half-life of BPC 157 is around 4 hours; therefore, the peptide can be dosed daily. Both oral and subcutaneous administration of BPC 157 have benefits since the peptide is highly stable through the digestive tract. However, if buying BPC 157 for muscle and tendon repair, local subcutaneous or intramuscular injection is recommended for optimal results.